Charlie is one of 11 dogs to date to undergo successful leg bone regrowth to repair a nonunion fracture.
Dr. Amy Kapatkin, chief of the Orthopedic Surgery Service,
has implemented the regrowth strategy in 11 dogs, with nine returning
to full function and two with acceptable function. All 11 cases involved
dogs with nonunion fractures in their limbs, meaning previous attempts
to repair their breaks failed to unite the bone as one again. All dogs
in the study had at least one previous surgery, while some had as many
as five previous attempts to heal their bone properly.
“Nonunion after long-bone fracture repair in dogs represents a
potentially devastating complication,” said Dr. Kapatkin. “We are
excited about this new treatment, and are optimistic that our use in
orthopedics can have the same long-term positive results our oral
surgeons have seen with jawbones.”
While not all regrowth surgeries are the same, the basic premise of the procedure is to place a scaffold (called a compression resistant matrix [CRM]) saturated with a bone morphogenetic protein (BMP) into the bone defect in hopes of stimulating additional bone growth from the surrounding, healthy native bone. The use of CRM and BMP specifically targeted areas of persistent bone defect after at least one failed surgery. Previously, the only additional treatment would be to try to set the break again in the same fashion with the dog’s own graft, which in many cases, carries the same potential fail rate due to a lack of blood supply to the bone.
“We look forward to the continued use of BMP to treat nonunion fractures,” said Dr. Kapatkin. “This initial success holds great promise for future patients – not just at UC Davis, but throughout the veterinary community.”
Dr. Kapatkin, along with other UC Davis surgeons (including the oral surgeons who pioneered BMP use at UC Davis) recently published a paper on the subject. Lead-authored by Dr. Anna Massie, a UC Davis surgery resident and Dr. Kapatkin’s mentee, the paper discusses the specifics of the 11 cases to date treated with this procedure. Dr. Massie presented the topic in poster form at the 2016 American College of Veterinary Surgery annual meeting, and won the Poster Presentation Award.
These cases at UC Davis represent the first large case series use of BMP to treat long bone nonunions in veterinary medicine. This exciting breakthrough is another example of how the UC Davis veterinary hospital is leading the way in discoveries of new treatments, and its commitment to advancing veterinary medicine to new heights.